FABON Pharma

DOUBLE CONE BLENDER

450,000.00

A Double Cone Blender is an essential blending machine in the pharmaceutical industry, ensuring homogeneous mixing of powders and granules with minimal material degradation. Its efficient tumbling motion, GMP-compliant design, and customizable features make it a reliable choice for tablet and capsule formulations.

DOUBLE CONE BLENDER: Technical Specification & Use in the Pharmaceutical Industry

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A Double Cone Blender is a widely used blending machine in the pharmaceutical industry for homogeneous mixing of dry powders and granules. It ensures uniform mixing with minimal material degradation, making it ideal for pharmaceutical, chemical, food, and nutraceutical applications.

Technical Specifications of Double Cone Blender

  • Construction Material
    • Stainless Steel (SS 316L for contact parts, SS 304 for non-contact parts) – ensures durability, compliance with GMP & FDA regulations, and resistance to corrosion.
    • Mirror/Matte Finish – facilitates easy cleaning and prevents material contamination.
    • CIP (Clean-in-Place) or SIP (Sterilize-in-Place) options – available for enhanced hygiene.
  • Blending Chamber (Double Cone Design)
    • Capacity: Available from 5 liters to 5,000 liters, depending on batch size.
    • Cone Angle: Optimized to ensure efficient tumbling action without dead spots.
    • Rotation Speed: Typically 8–25 RPM to ensure gentle and uniform mixing.
    • Baffles (Optional): Enhance mixing efficiency by preventing material layering.
  • Drive System
    • Motor & Gearbox Drive: Ensures smooth operation.
    • Motor Power: Ranges from 0.5 HP to 10 HP, depending on blender size.
    • Variable Frequency Drive (VFD) (Optional): Allows control of blending speed for different materials.
  • Loading & Unloading System
    • Manual or Vacuum Loading System – ensures efficient and dust-free material transfer.
    • Butterfly or Slide Valve for Discharge – enables easy and complete emptying of the blended material.
  • Control System
    • PLC-Based HMI Control Panel (Optional) – allows process automation.
    • Digital Timer & Speed Control – ensures repeatability and batch consistency.
  • Safety Features
    • Interlocking System: Prevents operation if the lid or discharge valve is open.
    • Emergency Stop Button: Ensures operator safety during operation.
    • Dust-Tight Seals: Prevents contamination and product loss.

Uses of Double Cone Blender in the Pharmaceutical Industry

  • Uniform Blending of Dry Powders & Granules: Ensures homogeneous mixing of API (Active Pharmaceutical Ingredients) and excipients for tablet and capsule formulations.
  • Ideal for Free-Flowing Powders: Best suited for dry, free-flowing powders and granules, ensuring even distribution of active ingredients.
  • Low Shear Mixing for Fragile Products: Gentle blending action prevents particle breakage – ideal for materials sensitive to mechanical stress.
  • Efficient Mixing for Large Batch Sizes: Used for blending bulk materials in tablet compression, granulation, and powder filling processes.
  • Pharmaceutical, Food, and Chemical Applications: Commonly used in industries requiring precise and contamination-free blending of powders.

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FAQs

What is a Double Cone Blender?
A Double Cone Blender is a rotating, conical-shaped vessel used to mix dry powders and granules homogeneously. It operates on the principle of tumbling, making it ideal for gentle and uniform blending of bulk materials in the pharmaceutical, nutraceutical, food, and chemical industries.
What are the main applications of a Double Cone Blender in pharma?
Blending API with excipients Homogenizing powdered or granular ingredients Preparing blends for tablet compression or capsule filling Suitable for fragile materials due to gentle blending action
How does a Double Cone Blender work?
The blender consists of two conical sections joined at the base. As the vessel rotates, the material tumbles, resulting in intermixing of contents by gravity. The asymmetrical shape enhances mixing efficiency while reducing segregation.
What are the key components of a Double Cone Blender?
Double cone-shaped rotating vessel Support frame with bearings Motor with reduction gearbox Discharge valve (butterfly or plug type) Charging port with dust-tight cover Control panel (manual or PLC-based)
What materials are used in construction?
Product contact parts: SS 316 or SS 316L Non-contact parts: SS 304 or powder-coated mild steel Surface finish: Mirror polish inside (Ra ≤ 0.5 µm), matte outside Seals and gaskets: FDA-approved EPDM or silicone
What batch sizes are available?
Double cone blenders come in various capacities: Lab scale: 5–25 liters Pilot scale: 50–200 liters Production scale: 250–2000+ liters Typically, the effective working volume is 50–60% of total capacity for best blending results.
What are the advantages of a Double Cone Blender?
Simple design and easy operation Gentle blending suitable for heat-sensitive or fragile materials Low maintenance with minimal moving parts Good batch-to-batch consistency Cost-effective compared to other blenders
What are the limitations of Double Cone Blenders?
Not ideal for very cohesive (sticky) powders Blending time can be longer compared to high-shear mixers Risk of segregation during discharge if not carefully designed Manual loading/unloading unless integrated with bins or vacuum transfer
What automation and safety features are available?
PLC + HMI control system (optional) Timer-based operation Interlocks for safety doors and overload protection Dust-tight seals and explosion-proof motors (optional) 21 CFR Part 11 compliance for electronic records (advanced models)
How is cleaning done?
Manual cleaning through access ports or removable covers Optional WIP (Wash-in-Place) system for faster turnaround FDA-compliant gaskets and welds for easy cleaning and no dead zones Cleaning validation required for multiproduct use
What validation and testing are required?
IQ/OQ/PQ documentation Blend uniformity testing (typically RSD ≤ 5%) Visual and surface residue inspections Cleaning validation protocols Rotation speed and timer calibration
What standards does it comply with?
cGMP (Current Good Manufacturing Practice) FDA 21 CFR Part 211 EU GMP Annex 11 ASME and CE (if applicable) ISPE and GAMP 5 guidelines
Can it be integrated with upstream/downstream systems?
Yes, many Double Cone Blenders can be integrated with: Vacuum loading systems IBC (bin) charging/discharging Sifters or mills Tablet compression or encapsulation lines
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