FABON Pharma

Dry Co Mill

250,000.00

Dry Co Mill (Conical Mill) is a critical milling equipment for accurate size reduction, de-lumping, and granulation in the pharma industry. With its reliable and GMP-compliant operation, it achieves uniform particle size distribution for tablets and capsules manufacture.

Dry Co Mill – Technical Specification & Application in the Pharmaceutical Industry

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Dry Co Mill (Conical Mill) is a highly efficient size reduction machine applied in pharmaceutical production for reducing size, granulating, and de-lumping of dry granules and powders. It ensures uniform particle size with little heat generation, which is suitable for products that are sensitive to heat used in tableting and capsule production.

Technical Specifications of Dry Co Mill

  1. Construction Material

Stainless Steel (SS 316L for contact components, SS 304 for non-contact components) – maintains GMP & FDA compliance.

Mirror or Matte Finish – does not allow contamination and is easy to clean.

Dust-Tight Seals – avoids cross-contamination of fine powders.

  1. Milling System

Conical Shaped Chamber – provides even and gentle size reduction.

Rotor Speed: 500–3000 RPM, adjustable according to material requirements.

Screen Sizes: 0.5 mm to 10 mm, interchangeable for various particle size outputs.

Knife & Impact Blades: For coarse and fine milling.

  1. Drive System

Motor Power: 1 to 10 HP, as the processing capacity is required.

Belt or Direct Drive Mechanism – for fluid and regulated handling.

Variable Frequency Drive (VFD) (Optional): Provisions for control of speed in order to enhance milling.

  1. Feed & Discharge System

Gravity or Vacuum Feeding System – regulates material supply.

Bottom Discharge with Collection Hopper or Vacuum Transfer System – facilitates easy material collection.

Feeding Mechanism: Hand feeding or screw conveyor feeding options.

  1. Capacity & Output

Batch Size: From 10 kg/hr to 2000 kg/hr, depending on the model.

Particle Size Reduction: 50 microns to 5 mm, depending on the screen to be used.

  1. Safety Features

Overload Protection – avoids motor damage.

Interlocking Mechanism – shuts off the machine if the cover is not closed.

Earthing & Static Charge Protection – keeps operator safe.

Applications of Dry Co Mill in the Pharmaceutical Industry

  • Granulation of Dry Powders: Transforms large particles into consistent granules for tablet compression and capsule filling.
  • De-Lumping of Granules: Disrupts agglomerates developed after drying, providing uniform granule size.
  • Size Reduction of Heat-Sensitive Materials: Reduces active pharmaceutical ingredients (APIs) and excipients without heat degradation.
  • Uniform Particle Size Distribution: Provides consistent flow properties for tablet and capsule manufacturing.
  • Reprocessing & Recycling: Utilized for reprocessing rejected tablets by size reduction for reuse.
  • Multi-Industry Applications: Used by pharmaceutical, food, chemical, and nutraceutical industries for controlled milling.

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FAQs

What is a Dry Co Mill?
A Dry Co Mill (Cone Mill or Co-mill) is a size reduction machine used for milling, delumping, and granule sizing in dry powder processing. It operates using a rotating impeller that pushes material through a screen to achieve uniform particle size.
What are the main applications of a Dry Co Mill in pharma?
Post fluid bed drying granule sizing De-lumping of agglomerated material Granule uniformity before compression or capsule filling Reclaiming and reprocessing of rejected tablets Fine milling of heat-sensitive and fragile materials
How does a Dry Co Mill work?
Material is fed into the hopper and moved by a rotating impeller towards a conical or round screen. As material passes through the perforations, particle size is reduced to the desired range through gentle shearing and cutting action.
What are the key components of a Dry Co Mill?
Feed hopper Rotating impeller (knife or paddle type) Screen (perforated or wire mesh cone) Discharge chute Motor and gearbox Control panel (manual or PLC-based) Caster wheels or fixed frame
What are the advantages of using a Dry Co Mill?
Gentle size reduction (minimal heat generation) Low dust generation Uniform granule size improves flow and compressibility Easy to clean and maintain Suitable for both batch and continuous processing
What materials are used in construction?
Product contact parts: SS 316 or SS 316L Non-contact parts: SS 304 or coated mild steel Gaskets and seals: FDA-compliant EPDM, silicone, or PTFE Surface finish: Mirror polish inside (Ra ≤ 0.5 µm)
What particle size range can it achieve?
Typically 100 μm to 1000 μm, depending on: Screen mesh size Impeller speed and design Material feed rate and properties
What are the types of screens available?
Perforated screen (round holes) Wire mesh screen Grater or rasp screen Screen types are selected based on the required particle size and product characteristics.
How is the equipment cleaned?
Manual cleaning by dismantling key components WIP (Wash-in-Place) options available for larger models Tool-less disassembly in many GMP models for quick turnaround Cleaning validation required for multi-product facilities
What safety features are included?
Overload protection for the motor Safety interlocks to prevent operation when the chamber is open Dust-tight design to protect operator and product Optional ATEX-compliant design for handling explosive dust
What validation is required for a Co Mill?
Design Qualification (DQ) Installation Qualification (IQ) Operational Qualification (OQ) Performance Qualification (PQ) Particle size distribution testing Cleaning and cross-contamination validation
What are common process issues and solutions?
Issue Cause Solution Uneven granules Worn screen or improper speed Replace screen; optimize RPM High dust Poor sealing or high impeller speed Check gaskets; reduce speed Product heating Excessive RPM or long run time Use gentler impeller or cool airflow
What standards and regulations does it meet?
cGMP (Current Good Manufacturing Practice) FDA 21 CFR Part 210/211 EU GMP Annex 11 CE and ATEX (if applicable) ISPE and GAMP 5 for automated versions
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